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p27 as a Transcriptional Regulator: New Roles in Development and Cancer

27 Apr 2020

Abstract excerpt

Abstract p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other processes including cell migration and development independent of its cyclin-dependent kinase (CDK) inhibitory action. p27 is an atypical tumor suppressor–deletion or mutational inactivation of the gene encoding p27, CDKN1B, is rare in human cancers. p27 is rarely fully lost in cancers because it can play both tumor...

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PMID: 32341036
DOI: 10.1158/0008-5472.can-19-3663

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