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Article

The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.

1 Oct 2009

Abstract excerpt

The potential for clinical application of pluripotent embryonic stem cells is immense but hampered by moral and ethical complications. Recent advances in the reprogramming of somatic cells by defined factors to a state that resemble embryonic stem cells have created tremendous excitement in the field. Four factors, Sox2, Oct4, Klf4 and c-Myc, when exogenously introduced into somatic cells, can lead to the...

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PMID: 19688699
DOI: 10.14670/hh-24.1343

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