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Article

Loss of p57 <sup>KIP2</sup> expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells

2 Dec 2019

Abstract excerpt

A complete hydatidiform mole (CHM) is androgenetic in origin and characterized by enhanced trophoblastic proliferation and the absence of fetal tissue. In 15 to 20% of cases, CHMs are followed by malignant gestational trophoblastic neoplasms including choriocarcinoma. Aberrant genomic imprinting may be responsible for trophoblast hypertrophy in CHMs, but the detailed mechanisms are still elusive, partly due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31792181
DOI: 10.1073/pnas.1916019116

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