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Article

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Nature - 16 Aug 2012

Mansour Abed AlFatah, Gafni Ohad, Weinberger Leehee, Zviran Asaf, Ayyash Muneef, Rais Yoach, Krupalnik Vladislav, Zerbib Mirie, Amann-Zalcenstein Daniela, Maza Itay, Geula Shay, Viukov Sergey, Holtzman Liad, Pribluda Ariel, Canaani Eli, Horn-Saban Shirley, Amit Ido, Novershtern Noa, Hanna Jacob H

Abstract excerpt

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by ectopic expression of different transcription factors, classically Oct4 (also known as Pou5f1), Sox2, Klf4 and Myc (abbreviated as OSKM). This process is accompanied by genome-wide epigenetic changes, but how these chromatin modifications are biochemically determined requires further investigation. Here we show in mice and humans that the...

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PMID: 22801502
DOI: 10.1038/nature11272

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.PMID 22801502Read ↗

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Utx loss causes myeloid transformation.Semantic proximity Read ↗

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.Semantic proximity Read ↗

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Semantic proximity Read ↗

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.Semantic proximity Read ↗

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.Semantic proximity Read ↗

UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome.Semantic proximity Read ↗

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The activation of a <i>Suv39h1</i> -repressive antisense lncRNA by OCT4 couples the control of H3K9 methylation to pluripotencySemantic proximity Read ↗

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The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation.Semantic proximity Read ↗

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