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Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background

30 Nov 2010

Abstract excerpt

Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1(Ter/Ter) mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto mixed background Dnd1(Ter/Ter) mutants, where teratomas do not typically develop, resulted in a high incidence of teratomas. However, when Dnd1(Ter/Ter); Bax(-/-) double mutants were...

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PMID: 21115610
DOI: 10.1242/dev.057000

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