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Article

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins.

Oncotarget - 20 Feb 2015

Vilas Jéssica M, Ferreirós Alba, Carneiro Carmen, Morey Lluis, Da Silva-Álvarez Sabela, Fernandes Tânia, Abad María, Di Croce Luciano, García-Caballero Tomás, Serrano Manuel, Rivas Carmen, Vidal Anxo, Collado Manuel

Abstract excerpt

Cellular reprogramming to iPSCs has uncovered unsuspected links between tumor suppressors and pluripotency factors. Using this system, it was possible to identify tumor suppressor p27 as a repressor of Sox2 during differentiation. This led to the demonstration that defects in the repression of Sox2 can contribute to tumor development. The members of the retinoblastoma family of pocket proteins, pRb, p107 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25576924
DOI: 10.18632/oncotarget.2996
PMCID: PMC4413632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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