Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation.

BMC veterinary research - 15 Nov 2012

Thorne Leigh, Holder Thomas, Ramsay Andrew, Edwards Jane, Taema Maged Mohamed, Windl Otto, Maddison Ben Charles, Gough Kevin Christopher, Terry Linda Ann

Abstract excerpt

BACKGROUND: Protein misfolding cyclic amplification (PMCA) is a method that facilitates the detection of prions from many sources of transmissible spongiform encephalopathy (TSE). Sheep scrapie represents a unique diversity of prion disease agents in a range of susceptible PRNP genotypes. In this study PMCA was assessed on a range of Great Britain (GB) sheep scrapie isolates to determine the applicability to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prions

Share to Protein Folding

Share to PrPSc Proteins

Share to Scrapie

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 23153009
DOI: 10.1186/1746-6148-8-223
PMCID: PMC3559253

Genes

PRNP
SSBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation.PMID 23153009Read ↗

Differentiating ovine BSE from CH1641 scrapie by serial protein misfolding cyclic amplification.Semantic proximity Read ↗

In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapieSemantic proximity Read ↗

Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies.Semantic proximity Read ↗

Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversion studies.Semantic proximity Read ↗

PrP(Sc) detection and infectivity in semen from scrapie-infected sheep.Semantic proximity Read ↗

BSE can propagate in sheep co-infected or pre-infected with scrapie.Semantic proximity Read ↗

Protein misfolding cyclic amplification corroborates the absence of PrPSc accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie.Semantic proximity Read ↗

A novel method for preclinical detection of PrPSc in blood.Semantic proximity Read ↗

In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate.Semantic proximity Read ↗

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion.Semantic proximity Read ↗

The oral secretion of infectious scrapie prions occurs in preclinical sheep with a range of PRNP genotypes.Semantic proximity Read ↗

De novo generation of infectious prions in vitro produces a new disease phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.