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Article

Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversion studies.

Journal of virology - 1 Mar 2014

Priem Jan, Langeveld Jan P M, van Keulen Lucien J M, van Zijderveld Fred G, Andreoletti Olivier, Bossers Alex

Abstract excerpt

UNLABELLED: Bovine spongiform encephalopathy (BSE) can be efficiently transmitted to small ruminants (sheep and goats) with certain prion protein (PrP) genotypes. Polymorphisms in PrP of both the host and donor influence the transmission efficiency of transmissible spongiform encephalopathies (TSEs) in general. These polymorphisms in PrP also modulate the PrP conversion underlying TSE agent replication. Here we...

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Identifiers

PMID: 24371051
DOI: 10.1128/JVI.02446-13
PMCID: PMC3958111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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