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In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie

13 Nov 2008

Abstract excerpt

Scrapie is a fatal, naturally transmissible, neurodegenerative prion disease that affects sheep and goats and is characterized by the accumulation of a misfolded protein, PrPSc, converted from host-encoded PrPc, in the central nervous system of affected animals. Highly efficient in vitro conversion of host PrPc to PrPSc has been achieved in models of scrapie and in natural prion diseases by protein misfolding...

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PMID: 19008409
DOI: 10.1099/vir.0.2008/004226-0

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