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Article

The oral secretion of infectious scrapie prions occurs in preclinical sheep with a range of PRNP genotypes.

Journal of virology - 1 Jan 2012

Gough Kevin C, Baker Claire A, Rees Helen C, Terry Linda A, Spiropoulos John, Thorne Leigh, Maddison Ben C

Abstract excerpt

Preclinical sheep with the highly scrapie-susceptible VRQ/VRQ PRNP genotype secrete prions from the oral cavity. In order to further understand the significance of orally available prions, buccal swabs were taken from sheep with a range of PRNP genotypes and analyzed by serial protein misfolding cyclic amplification (sPMCA). Prions were detected in buccal swabs from scrapie-exposed sheep of genotypes linked to...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22013047
DOI: 10.1128/JVI.05579-11
PMCID: PMC3255911

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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