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Article

BSE can propagate in sheep co-infected or pre-infected with scrapie.

Scientific reports - 7 Jun 2021

Chong Angela, Foster James D, Goldmann Wilfred, Gonzalez Lorenzo, Jeffrey Martin, O'Connor Matthew J, Bishop Keith, Maddison Ben C, Houston E Fiona, Gough Kevin C, Hunter Nora

Abstract excerpt

To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneously into sheep with ARQ/ARQ or VRQ/ARQ PRNP genotypes either at the same time as subcutaneous challenge with scrapie, or three months later. In addition, VRQ/VRQ sheep naturally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34099797
DOI: 10.1038/s41598-021-91397-8
PMCID: PMC8184847

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