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Article

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion.

The Journal of general virology - 1 Nov 2017

Haley Nicholas J, Rielinger Rachel, Davenport Kristen A, O'Rourke Katherine, Mitchell Gordon, Richt Jürgen A

Abstract excerpt

In mammals, susceptibility to prion infection is primarily modulated by the host's cellular prion protein (PrPC) sequence. In the sheep scrapie model, a graded scale of susceptibility has been established both in vivo and in vitro based on PrPC amino acids 136, 154 and 171, leading to global breeding programmes to reduce the prevalence of scrapie in sheep. Chronic wasting disease (CWD) resistance in cervids is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29058651
DOI: 10.1099/jgv.0.000952
PMCID: PMC5845664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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