Article
De novo generation of infectious prions in vitro produces a new disease phenotype.
PLoS pathogens - 1 May 2009
Barria Marcelo A, Mukherjee Abhisek, Gonzalez-Romero Dennisse, Morales Rodrigo, Soto Claudio
Abstract excerpt
Prions are the proteinaceous infectious agents responsible for Transmissible Spongiform Encephalopathies. Compelling evidence supports the hypothesis that prions are composed exclusively of a misfolded version of the prion protein (PrP(Sc)) that replicates in the body in the absence of nucleic acids by inducing the misfolding of the cellular prion protein (PrP(C)). The most common form of human prion disease is...
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