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Article

A novel method for preclinical detection of PrPSc in blood.

The Journal of general virology - 1 Jul 2010

Rubenstein Richard, Chang Binggong, Gray Perry, Piltch Martin, Bulgin Marie S, Sorensen-Melson Sharon, Miller Michael W

Abstract excerpt

In this study, we demonstrate that a moderate amount of protein misfolding cyclic amplification (PMCA) coupled to a novel surround optical fibre immunoassay (SOFIA) detection scheme can be used to detect the disease-associated form of the prion protein (PrP(Sc)) in protease-untreated plasma from preclinical and clinical scrapie sheep, and white-tailed deer with chronic wasting disease, following natural and...

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Identifiers

PMID: 20357038
DOI: 10.1099/vir.0.020164-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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