Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiating ovine BSE from CH1641 scrapie by serial protein misfolding cyclic amplification.

Molecular biotechnology - 1 Jul 2012

Taema Maged M, Maddison Ben C, Thorne Leigh, Bishop Keith, Owen Jonathan, Hunter Nora, Baker Claire A, Terry Linda A, Gough Kevin C

Abstract excerpt

Whilst ovine BSE displays distinct pathological characteristics to ovine CH1641-like scrapie upon passage in rodents, they have very similar molecular phenotypes. As such, the in vitro differentiation of these strains in routine surveillance programmes presents a significant diagnostic challenge. In this study, using serial protein-misfolding cyclic amplification (sPMCA), ovine BSE was readily amplified in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Encephalopathy, Bovine Spongiform

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Typing

Share to Prions

Share to Protein Folding

Share to Scrapie

Share to Sequence Analysis, Protein

Share to Sheep, Domestic

Source

Identifiers

PMID: 21987099
DOI: 10.1007/s12033-011-9460-0

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiating ovine BSE from CH1641 scrapie by serial protein misfolding cyclic amplification.PMID 21987099Read ↗

In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation.Semantic proximity Read ↗

Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies.Semantic proximity Read ↗

Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversion studies.Semantic proximity Read ↗

In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate.Semantic proximity Read ↗

Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage.Semantic proximity Read ↗

Selective amplification of classical and atypical prions using modified protein misfolding cyclic amplification.Semantic proximity Read ↗

In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapieSemantic proximity Read ↗

De novo generation of infectious prions in vitro produces a new disease phenotype.Semantic proximity Read ↗

BSE can propagate in sheep co-infected or pre-infected with scrapie.Semantic proximity Read ↗

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.Semantic proximity Read ↗

L-BSE experimentally transmitted to sheep presents as a unique disease phenotype.Semantic proximity Read ↗

In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.