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Article

Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies.

Journal of virology - 1 Aug 2011

Bucalossi Cecilia, Cosseddu Gianmario, D'Agostino Claudia, Di Bari Michele Angelo, Chiappini Barbara, Conte Michela, Rosone Francesca, De Grossi Luigi, Scavia Gaia, Agrimi Umberto, Nonno Romolo, Vaccari Gabriele

Abstract excerpt

The susceptibility of sheep to scrapie is influenced mainly by the prion protein polymorphisms A136V, R154H, and Q171R/H. Here we analyzed the ability of protein misfolding cyclic amplification (PMCA) to model the genetic susceptibility of sheep to scrapie. For this purpose, we studied the efficiency of brain homogenates from sheep with different PrP genotypes to support PrP(Sc) amplification by PMCA using an...

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Identifiers

PMID: 21680531
DOI: 10.1128/JVI.00241-11
PMCID: PMC3147950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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