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Article

Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.

BMC immunology - 8 Nov 2012

Zschemisch Nils-Holger, Glage Silke, Wedekind Dirk, Weinstein Edward J, Cui Xiaoxia, Dorsch Martina, Hedrich Hans-Jürgen

Abstract excerpt

BACKGROUND: Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or cytoplasmatic microinjection into zygotes. Resulting frame shift mutations led to functional gene ablations in zebra fish, mice, pigs and also in laboratory rats....

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Source

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Identifiers

PMID: 23136839
DOI: 10.1186/1471-2172-13-60
PMCID: PMC3522011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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