Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL).

Genesis (New York, N.Y. : 2000) - 1 Dec 2007

Wu Xiaoli, Sandhu Sumit, Ding Hao

Abstract excerpt

Regulator of telomere length (RTEL) is a DNA helicase-like protein that has recently been demonstrated to be required for the maintenance of telomere length and genomic stability. Rtel null mice are embryonic lethal with the defects in the nervous system, the heart, the vasculature, and extra-embryonic tissues. Rtel could also be important for the postnatal development as its expression is strongly induced in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Helicases
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Mice, Knockout

Source

Identifiers

PMID: 18064678
DOI: 10.1002/dvg.20359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL).PMID 18064678Read ↗

Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.Semantic proximity Read ↗

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomeraseSemantic proximity Read ↗

The molecular genetics of the telomere biology disorders.Semantic proximity Read ↗

Human Specific Regulation of the Telomerase Reverse Transcriptase GeneSemantic proximity Read ↗

Telomerase Is Required for Zebrafish LifespanSemantic proximity Read ↗

Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.Semantic proximity Read ↗

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.Semantic proximity Read ↗

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1Semantic proximity Read ↗

Humanization of the mouse telomerase gene reset telomeres to human lengthSemantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Semantic proximity Read ↗

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human lengthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.