Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.

PloS one - 1 Jan 2014

Ponce de León Verónica, Mérillat Anne-Marie, Tesson Laurent, Anegón Ignacio, Hummler Edith

Abstract excerpt

Transcription Activator-Like Effector Nucleases (TALEN) are potential tools for precise genome engineering of laboratory animals. We report the first targeted genomic integration in the rat using TALENs (Transcription Activator-Like Effector Nucleases) by homology-derived recombination (HDR). We assembled TALENs and designed a linear donor insert targeting a pA476T mutation in the rat Glucocorticoid Receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Endonucleases
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Homologous Recombination

Share to Protein Multimerization

Share to Rats, Sprague-Dawley

Share to Receptors, Glucocorticoid

Source

Open in PubMed Open full text

Identifiers

PMID: 24523878
DOI: 10.1371/journal.pone.0088146
PMCID: PMC3921256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.PMID 24523878Read ↗

Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.Semantic proximity Read ↗

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.Semantic proximity Read ↗

Generation of site-specific mutations in the rat genome via CRISPR/Cas9.Semantic proximity Read ↗

GRK5-Knockout Mice Generated by TALEN-Mediated Gene Targeting.Semantic proximity Read ↗

CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos.Semantic proximity Read ↗

One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor.Semantic proximity Read ↗

i-GONAD (improved genome-editing via oviductal nucleic acids delivery), a convenient in vivo tool to produce genome-edited rats.Semantic proximity Read ↗

Genetic modification and screening in rat using haploid embryonic stem cells.Semantic proximity Read ↗

Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes.Semantic proximity Read ↗

Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation.Semantic proximity Read ↗

Generation of TALEN-mediated FH knockout rat model.Semantic proximity Read ↗

A Novel Patient-Derived Mutation in Glucocorticoid Receptor Reveals an Essential Role for DNA binding in Development and Endocrine RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.