Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

doi:10.1371/journal.pone.0164206

Article

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

PloS one - 1 Jan 2016

Liška František, Peterková Renata, Peterka Miroslav, Landa Vladimír, Zídek Václav, Mlejnek Petr, Šilhavý Jan, Šimáková Miroslava, Křen Vladimír, Starker Colby G, Voytas Daniel F, Izsvák Zsuzsanna, Pravenec Michal

Abstract excerpt

Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of the Plzf (Promyelocytic leukemia zinc finger protein) gene. In addition, Plzf is a prominent candidate gene for quantitative trait loci (QTLs) associated with cardiac hypertrophy and fibrosis in the spontaneously hypertensive rat (SHR). In the current...

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Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

Abstract excerpt

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