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Article

Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.

Transgenic research - 1 Aug 2016

Goto Teppei, Hara Hiromasa, Nakauchi Hiromitsu, Hochi Shinichi, Hirabayashi Masumi

Abstract excerpt

The Foxn1 gene is known as a critical factor for the differentiation of thymic and skin epithelial cells. This study was designed to examine the phenotype of Foxn1-modified rats generated by the CRISPR/Cas9 system. Guide-RNA designed for first exon of the Foxn1 and mRNA of Cas9 were co-injected into the pronucleus of Crlj:WI zygotes. Transfer of 158 injected zygotes resulted in the birth of 50 offspring (32 %),...

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PMID: 26931321
DOI: 10.1007/s11248-016-9941-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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