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Article

Characterization of immunoglobulin heavy chain knockout rats

9 Sept 2010

Abstract excerpt

The rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene-specific mutations. In a recent study, we described for the first time the generation of novel rat lines with targeted mutations using zinc-finger nucleases. In this study, we compare immune development in two Ig heavy-chain KO lines; one with truncated Cμ and a new line with removed JH...

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PMID: 21038471
DOI: 10.1002/eji.201040939

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