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Article

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases.

PloS one - 25 Jan 2010

Mashimo Tomoji, Takizawa Akiko, Voigt Birger, Yoshimi Kazuto, Hiai Hiroshi, Kuramoto Takashi, Serikawa Tadao

Abstract excerpt

BACKGROUND: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucleases (ZFNs) were successfully used to create ge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rats, Inbred F344

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Source

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Identifiers

PMID: 20111598
DOI: 10.1371/journal.pone.0008870
PMCID: PMC2810328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20111598-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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