Coronary Heart Disease and Genetic Variants with Low Phospholipase A₂ Activity

Abstract excerpt

To the Editor: Genetic studies, particularly studies of rare loss-of-function variants, have been good predictors of the success of targeted drugs that lower levels of risk factors and the risk of disease. 1,2 Lipoprotein-associated phospholipase A 2 , which is encoded by the PLA2G7 gene, hydrolyzes oxidized phosphatidylcholine to release oxidized nonesterified fatty acids and lysophosphatidylcholine, which...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetes, Cardiovascular Risks, and Lipoproteins
• Share to Lipoproteins and Cardiovascular Health
• Share to Protein Kinase Regulation and GTPase Signaling