LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.

doi:10.1161/CIRCULATIONAHA.117.031356

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Article

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins.

Circulation - 23 Oct 2018

Wei Wei-Qi, Li Xiaohui, Feng Qiping, Kubo Michiaki, Kullo Iftikhar J, Peissig Peggy L, Karlson Elizabeth W, Jarvik Gail P, Lee Ming Ta Michael, Shang Ning, Larson Eric A, Edwards Todd, Shaffer Christian M, Mosley Jonathan D, Maeda Shiro, Horikoshi Momoko, Ritchie Marylyn, Williams Marc S, Larson Eric B, Crosslin David R, Bland Harris T, Pacheco Jennifer A, Rasmussen-Torvik Laura J, Cronkite David, Hripcsak George, Cox Nancy J, Wilke Russell A, Stein C Michael, Rotter Jerome I, Momozawa Yukihide, Roden Dan M, Krauss Ronald M, Denny Joshua C

Abstract excerpt

BACKGROUND: Coronary heart disease (CHD) is a leading cause of death globally. Although therapy with statins decreases circulating levels of low-density lipoprotein cholesterol and the incidence of CHD, additional events occur despite statin therapy in some individuals. The genetic determinants of this residual cardiovascular risk remain unknown. METHODS: We performed a 2-stage genome-wide association study of...

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PMID: 29703846
DOI: 10.1161/CIRCULATIONAHA.117.031356
PMCID: PMC6202211

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