Article
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
Circulation. Cardiovascular genetics - 1 Apr 2012
Chasman Daniel I, Giulianini Franco, MacFadyen Jean, Barratt Bryan J, Nyberg Fredrik, Ridker Paul M
Abstract excerpt
BACKGROUND: In statin trials, each 20 mg/dL reduction in cholesterol results in a 10-15% reduction of annual incidence rates for vascular events. However, interindividual variation in low-density lipoprotein cholesterol (LDL-C) response to statins is wide and may partially be determined on a genetic basis. METHODS AND RESULTS: A genome-wide association study of LDL-C response was performed among a total of 6989...
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