Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.

doi:10.1002/mds.25226

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Article

Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2012

Mata Ignacio F, Checkoway Harvey, Hutter Carolyn M, Samii Ali, Roberts John W, Kim Hojoong M, Agarwal Pinky, Alvarez Victoria, Ribacoba Renee, Pastor Pau, Lorenzo-Betancor Oswaldo, Infante Jon, Sierra María, Gómez-Garre Pilar, Mir Pablo, Ritz Beate, Rhodes Shannon L, Colcher Amy, Van Deerlin Vivianna, Chung Kathryn A, Quinn Joseph F, Yearout Dora, Martinez Erica, Farin Federico M, Wan Jia Y, Edwards Karen L, Zabetian Cyrus P

Abstract excerpt

BACKGROUND: Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear. METHODS: We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P < .05) were then genotyped in an independent sample of...

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PMID: 23115130
DOI: 10.1002/mds.25226
PMCID: PMC3536918

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Source receipt: pubmed, retrieved 7 Sept 2026.

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