Article
Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2013
Heckman Michael G, Soto-Ortolaza Alexandra I, Aasly Jan O, Abahuni Nadine, Annesi Grazia, Bacon Justin A, Bardien Soraya, Bozi Maria, Brice Alexis, Brighina Laura, Carr Jonathan, Chartier-Harlin Marie-Christine, Dardiotis Efthimios, Dickson Dennis W, Diehl Nancy N, Elbaz Alexis, Ferrarese Carlo, Fiske Brian, Gibson J Mark, Gibson Rachel, Hadjigeorgiou Georgios M, Hattori Nobutaka, Ioannidis John P A, Boczarska-Jedynak Magdalena, Jasinska-Myga Barbara, Jeon Beom S, Kim Yun Joong, Klein Christine, Kruger Rejko, Kyratzi Elli, Lesage Suzanne, Lin Chin-Hsien, Lynch Timothy, Maraganore Demetrius M, Mellick George D, Mutez Eugénie, Nilsson Christer, Opala Grzegorz, Park Sung Sup, Petrucci Simona, Puschmann Andreas, Quattrone Aldo, Sharma Manu, Silburn Peter A, Sohn Young Ho, Stefanis Leonidas, Tadic Vera, Theuns Jessie, Tomiyama Hiroyuki, Uitti Ryan J, Valente Enza Maria, Van Broeckhoven Christine, van de Loo Simone, Vassilatis Demetrios K, Vilariño-Güell Carles, White Linda R, Wirdefeldt Karin, Wszolek Zbigniew K, Wu Ruey-Meei, Hentati Faycal, Farrer Matthew J, Ross Owen A
Abstract excerpt
BACKGROUND: Variants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. METHODS: The Genetic Epidemiology of Parkinson's Disease Consortium recently performed...
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