LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.

doi:10.1002/mds.22514

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Article

LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 15 May 2009

Zabetian Cyrus P, Yamamoto Mitsutoshi, Lopez Alexis N, Ujike Hiroshi, Mata Ignacio F, Izumi Yuishin, Kaji Ryuji, Maruyama Hirofumi, Morino Hiroyuki, Oda Masaya, Hutter Carolyn M, Edwards Karen L, Schellenberg Gerard D, Tsuang Debby W, Yearout Dora, Larson Eric B, Kawakami Hideshi

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic determinant of Parkinson's disease (PD) in European-derived populations, but far less is known about LRRK2 mutations and susceptibility alleles in Asians. To address this issue, we sequenced the LRRK2 coding re...

Topics

Aged
Arginine
DNA Mutational Analysis
Exons
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Glycine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Male

Meta-Analysis as Topic

Middle Aged

Models, Statistical

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 19343804
DOI: 10.1002/mds.22514
PMCID: PMC2827255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19343804-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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