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Article

Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

Parkinsonism & related disorders - 1 Mar 2007

Farrer Matthew J, Stone Jeremy T, Lin Chin-Hsien, Dächsel Justus C, Hulihan Mary M, Haugarvoll Kristoffer, Ross Owen A, Wu Ruey-Meei

Abstract excerpt

The goal of genetic association studies is to identify common (>5%) risk factors in complex disease traits. Herein we describe the first replicable 'functional' risk allele for Parkinson's disease. The leucine-rich repeat kinase 2 (Lrrk2) G2385R substitution is associated with familial parkinsonism, late-, and early-onset Parkinson's disease in ethnic Chinese Taiwanese. Crucially, we provide evidence of...

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Identifiers

PMID: 17222580
DOI: 10.1016/j.parkreldis.2006.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.Semantic proximity Read ↗

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