Article
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
The Lancet. Neurology - 1 Oct 2011
Ross Owen A, Soto-Ortolaza Alexandra I, Heckman Michael G, Aasly Jan O, Abahuni Nadine, Annesi Grazia, Bacon Justin A, Bardien Soraya, Bozi Maria, Brice Alexis, Brighina Laura, Van Broeckhoven Christine, Carr Jonathan, Chartier-Harlin Marie-Christine, Dardiotis Efthimios, Dickson Dennis W, Diehl Nancy N, Elbaz Alexis, Ferrarese Carlo, Ferraris Alessandro, Fiske Brian, Gibson J Mark, Gibson Rachel, Hadjigeorgiou Georgios M, Hattori Nobutaka, Ioannidis John P A, Jasinska-Myga Barbara, Jeon Beom S, Kim Yun Joong, Klein Christine, Kruger Rejko, Kyratzi Elli, Lesage Suzanne, Lin Chin-Hsien, Lynch Timothy, Maraganore Demetrius M, Mellick George D, Mutez Eugénie, Nilsson Christer, Opala Grzegorz, Park Sung Sup, Puschmann Andreas, Quattrone Aldo, Sharma Manu, Silburn Peter A, Sohn Young Ho, Stefanis Leonidas, Tadic Vera, Theuns Jessie, Tomiyama Hiroyuki, Uitti Ryan J, Valente Enza Maria, van de Loo Simone, Vassilatis Demetrios K, Vilariño-Güell Carles, White Linda R, Wirdefeldt Karin, Wszolek Zbigniew K, Wu Ruey-Meei, Farrer Matthew J
Abstract excerpt
BACKGROUND: Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the...
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