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Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population.

Neurobiology of aging - 1 Dec 2018

Zhang Jin-Ru, Jin Hong, Li Kai, Mao Cheng-Jie, Yang Ya-Ping, Wang Fen, Gu Chen-Chen, Zhang Hui-Jun, Chen Jing, Liu Chun-Feng

Abstract excerpt

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent genetic factors contributing to Parkinson's disease (PD). The aim of our study was to explore LRRK2 variants in PD patients within the mainland Han Chinese population. The whole coding regions of LRRK2 from 296 PD patients were sequenced by targeted regions sequencing and exome sequencing. Eighteen rare variants were identified...

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PMID: 30049590
DOI: 10.1016/j.neurobiolaging.2018.06.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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