Article
Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population.
Neurobiology of aging - 1 Dec 2018
Zhang Jin-Ru, Jin Hong, Li Kai, Mao Cheng-Jie, Yang Ya-Ping, Wang Fen, Gu Chen-Chen, Zhang Hui-Jun, Chen Jing, Liu Chun-Feng
Abstract excerpt
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent genetic factors contributing to Parkinson's disease (PD). The aim of our study was to explore LRRK2 variants in PD patients within the mainland Han Chinese population. The whole coding regions of LRRK2 from 296...
Topics
- Adult
- Aged
- China
- Female
- High-Throughput Nucleotide Sequencing
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Parkinson Disease
- Phenotype
- Sequence Analysis, DNA