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Article

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2022

Lake Julie, Reed Xylena, Langston Rebekah G, Nalls Mike A, Gan-Or Ziv, Cookson Mark R, Singleton Andrew B, Blauwendraat Cornelis, Leonard Hampton L

Abstract excerpt

BACKGROUND: The leucine-rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg, rs76904798) with lower effect sizes that are associated with Parkinson's disease (PD) risk. OBJECTIVES: This study aimed to investigate in a large meta-analysis whether the LRRK2 Genome-Wide Association Study (GWAS) signal represented by rs76904798 is...

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Identifiers

PMID: 34542912
DOI: 10.1002/mds.28787
PMCID: PMC9292230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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