Article
Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
Human mutation - 1 May 2010
Tan Eng-King, Peng Rong, Teo Yik-Ying, Tan Louis C, Angeles Dario, Ho Patrick, Chen Meng-Ling, Lin Chin-Hsien, Mao Xue-Ye, Chang Xue-Li, Prakash Kumar M, Liu Jian-Jun, Au Wing-Lok, Le Wei-Dong, Jankovic Joseph, Burgunder Jean-Marc, Zhao Yi, Wu Ruey-Meei
Abstract excerpt
We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R and rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent. Focusing exclusively on Han Chinese, we first sequenced the coding regions in young onset and familial PD patients and identified 59 variants....
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