Article
LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Neurology - 13 Sept 2005
Paisán-Ruíz C, Lang A E, Kawarai T, Sato C, Salehi-Rad S, Fisman G K, Al-Khairallah T, St George-Hyslop P, Singleton A, Rogaeva E
Abstract excerpt
BACKGROUND: In addition to the four well-confirmed genes linked to early-onset Parkinson disease (PD) (SNCA, PARKIN, DJ-1, and PINK1), mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have recently been identified in families with autosomal dominant late-onset PD. OBJECTIVE: To perform...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Apolipoproteins E
- Case-Control Studies
- DNA Mutational Analysis
- Exons
- Family Health
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Middle Aged
- Mutation
- Parkinson Disease