Article
LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Neurology - 13 Sept 2005
Paisán-Ruíz C, Lang A E, Kawarai T, Sato C, Salehi-Rad S, Fisman G K, Al-Khairallah T, St George-Hyslop P, Singleton A, Rogaeva E
Abstract excerpt
BACKGROUND: In addition to the four well-confirmed genes linked to early-onset Parkinson disease (PD) (SNCA, PARKIN, DJ-1, and PINK1), mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have recently been identified in families with autosomal dominant late-onset PD. OBJECTIVE: To perform mutation analysis of LRRK2 in probands of families showing dominant inheritance of PD and to conduct a case control...
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