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Article

Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson's Disease.

Advances in neurobiology - 1 Jan 2017

Monfrini Edoardo, Di Fonzo Alessio

Abstract excerpt

The discovery of LRRK2 mutations as a cause of Parkinson's disease (PD), including the sporadic late-onset form, established the decisive role of genetics in the field of PD research. Among LRRK2 mutations, the G2019S, mostly lying in a haplotype originating from a common Middle Eastern ancestor, has been identified in different populations worldwide. The G2385R and R1628P variants represent validated risk...

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PMID: 28353276
DOI: 10.1007/978-3-319-49969-7_1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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