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Article

Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease.

PloS one - 1 Jan 2012

Zhuang Jianhui, Peng Wenhui, Li Hailing, Wang Wei, Wei Yidong, Li Weiming, Xu Yawei

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified that multiple single nucleiotide polymorphisms on chromosome 9p21 are tightly associated with coronary artery disease (CAD). However, the mechanism linking this risk locus to CAD remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: The methylation status of six candidate genes (BAX, BCL-2, TIMP3, p14(ARF), p15(INK4b) and p16(INK4a)) in 205 patients and...

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Share to Chromosomes, Human, Pair 9
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Epigenesis, Genetic

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Share to RNA, Long Noncoding

Source

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Identifiers

PMID: 23091611
DOI: 10.1371/journal.pone.0047193
PMCID: PMC3473029

Genes

CAD
BAX
TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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