Article
The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications.
Current pharmaceutical design - 1 Jan 2016
Tajbakhsh Amir, Khorrami Mohammad Sadegh, Hassanian Seyed Mahdi, Aghasizade Malihe, Pasdar Alireza, Maftouh Mina, Tabatabai Ehsan, Parizadeh Seyed Mohammad Reza, Fazeli Mostafa, Ferns Gordon A, Ghayour-Mobarhan Majid, Avan Amir
Abstract excerpt
Cardiovascular disease (CVD) is the leading cause of global mortality. Although extensive efforts have been made to identify valid biomarkers for CVD risk, relatively few are of proven clinical utility. It is recognized that genetic factors play a major role in determining the susceptibility to CVD. Recent genome-wide-association-studies have demonstrated common genetic variants in a region on chromosome 9p21...
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