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Article

Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors.

BMC medical genomics - 6 Oct 2021

Xu Bayi, Xu Zhixia, Chen Yequn, Lu Nan, Shu Zhouwu, Tan Xuerui

Abstract excerpt

BACKGROUND: Both DNA genotype and methylation of antisense non-coding RNA in the INK4 locus (ANRIL) have been robustly associated with coronary artery disease (CAD), but the interdependent mechanisms of genotype and methylation remain unclear. METHODS: Eighteen tag single nucleotide polymorphisms (SNPs) of ANRIL were genotyped in a matched case-control study (cases 503 and controls 503). DNA methylation of ANRIL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34615528
DOI: 10.1186/s12920-021-01094-8
PMCID: PMC8496081

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