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Article

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.

PloS one - 1 Jan 2009

Liu Yan, Sanoff Hanna K, Cho Hyunsoon, Burd Christin E, Torrice Chad, Mohlke Karen L, Ibrahim Joseph G, Thomas Nancy E, Sharpless Norman E

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have linked common single nucleotide polymorphisms (SNPs) on chromosome 9p21 near the INK4/ARF (CDKN2A/B) tumor suppressor locus with risk of atherosclerotic diseases and type 2 diabetes mellitus. To explore the mechanism of this association, we investigated whether expression of proximate transcripts (p16(INK4a), p15(INK4b), ARF, ANRIL and MTAP) correlate with...

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Identifiers

PMID: 19343170
DOI: 10.1371/journal.pone.0005027
PMCID: PMC2660422

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.PMID 19343170Read ↗

ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.Semantic proximity Read ↗

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Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.Semantic proximity Read ↗

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Transcriptional regulation of INK4/ARF locus by cis and trans mechanismsSemantic proximity Read ↗

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The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region.Semantic proximity Read ↗

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