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Article

Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.

PloS one - 1 Jan 2012

Basu Madhumita, Das Tania, Ghosh Alip, Majumder Subhadipa, Maji Ardhendu Kumar, Kanjilal Sumana Datta, Mukhopadhyay Indranil, Roychowdhury Susanta, Banerjee Soma, Sengupta Sanghamitra

Abstract excerpt

Genetic variations in toll-like receptors and cytokine genes of the innate immune pathways have been implicated in controlling parasite growth and the pathogenesis of Plasmodium falciparum mediated malaria. We previously published genetic association of TLR4 non-synonymous and TNF-α promoter polymorphisms with P.falciparum blood infection level and here we extend the study considerably by (i) investigating...

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Identifiers

PMID: 23071570
DOI: 10.1371/journal.pone.0046441
PMCID: PMC3470565

Genes

TNF
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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