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Article

Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults.

Immunogenetics - 1 Jun 2010

Phawong Chintana, Ouma Collins, Tangteerawatana Piyatida, Thongshoob Jarinee, Were Tom, Mahakunkijcharoen Yuvadee, Wattanasirichaigoon Duangrurdee, Perkins Douglas Jay, Khusmith Srisin

Abstract excerpt

Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3' UTR T/G (rs3212227)], severe malaria and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to 3' Untranslated Regions
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Share to Interferon-gamma
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Identifiers

PMID: 20387064
DOI: 10.1007/s00251-010-0439-y
PMCID: PMC3057425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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