Article
TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon.
Malaria journal - 13 Mar 2017
Brasil Larissa W, Barbosa Laila R A, de Araujo Felipe J, da Costa Allyson G, da Silva Luan D O, Pinheiro Suzana K, de Almeida Anne C G, Kuhn Andrea, Vitor-Silva Sheila, de Melo Gisely C, Monteiro Wuelton M, de Lacerda Marcus V G, Ramasawmy Rajendranath
Abstract excerpt
BACKGROUND: Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common TOLLIP polymorphisms (rs5743899 and rs3750920) were reported to be influencing IL-6, TNF and IL-10 expression. In this study, TOLLIP variants were investigated to their relation to Plasmodium...
Read the complete abstract on PubMed