Association of toll like receptors polymorphism (TLR1-rs4833095, TLR1-rs5743611, TLR6-rs5743810, TLR6-rs5743809, TLR4-rs4986790, TLR4-rs4986791, TLR9 rs187084) with clinical outcome of malaria among children in Ibadan, Southwest Nigeria.

Abstract excerpt

Different genetic polymorphisms, particularly in the erythrocyte receptors and immune response-related genes, have been implicated in the development of malaria. With the first immune response to Plasmodium falciparum related to the activity of toll-like receptors (TLRs), we investigated the association of TLR polymorphisms with the clinical outcome of malaria among 662 children in Ibadan, Nigeria. The...

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