Article
Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection.
Immunogenetics - 1 Feb 2018
Ojurongbe Olusola, Funwei Roland I, Snyder Tara J, Farid Iman, Aziz Najihah, Li Yi, Falade Catherine O, Thomas Bolaji N
Abstract excerpt
Susceptibility to malaria infection has been associated with host genetic polymorphisms that differs between groups. We hypothesize that Toll-interacting proteins (TOLLIP), vitamin D receptor (VDR) and tumor necrosis factor-α (TNF) genes are significant contributors to susceptibility and disease severity in Plasmodium falciparum (Pf) infection. Our aim is to explore the genomic diversity and haplotype frequency...
Topics
- Adult
- Africa South of the Sahara
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Intracellular Signaling Peptides and Proteins
- Malaria
- Malaria, Falciparum