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Article

Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults.

Neurology - 16 Oct 2012

Lim Yen Ying, Ellis Kathryn A, Pietrzak Robert H, Ames David, Darby David, Harrington Karra, Martins Ralph N, Masters Colin L, Rowe Christopher, Savage Greg, Szoeke Cassandra, Villemagne Victor L, Maruff Paul

Abstract excerpt

OBJECTIVE: Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear. METHODS: Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23071163
DOI: 10.1212/WNL.0b013e31826e9ae6

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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