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Subjective Memory Complaints in APOE ɛ 4 Carriers are Associated with High Amyloid-β Burden

25 Nov 2015

Abstract excerpt

BACKGROUND: APOEɛ4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning. OBJECTIVE: To assess whether APOEɛ4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly. METHODS: 307...

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PMID: 26639956
DOI: 10.3233/jad-150446

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