Article
APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease.
Molecular psychiatry - 1 Nov 2015
Lim Y Y, Villemagne V L, Laws S M, Pietrzak R H, Snyder P J, Ames D, Ellis K A, Harrington K, Rembach A, Martins R N, Rowe C C, Masters C L, Maruff P
Abstract excerpt
Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer's disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 carrier[ɛ4(+)], ɛ4 non-carrier[ɛ4(-)]) and brain-derived neurotrophic factor (BDNF(Val/Val), BDNF(Met)) in the extent to which they moderate Aβ-related memory decline. Healthy adults...
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