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Article

Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2016

Mielke Michelle M, Machulda Mary M, Hagen Clinton E, Christianson Teresa J, Roberts Rosebud O, Knopman David S, Vemuri Prashanthi, Lowe Val J, Kremers Walter K, Jack Clifford R, Petersen Ronald C

Abstract excerpt

INTRODUCTION: Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals. METHODS: We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, mean age of 62.7 (range, 51-71 years), enrolled in the Mayo Clinic Study of Aging. Participants completed multiple cognitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26602629
DOI: 10.1016/j.jalz.2015.09.010
PMCID: PMC4850495

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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