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Article

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Lim Yen Ying, Williamson Robert, Laws Simon M, Villemagne Victor L, Bourgeat Pierrick, Fowler Christopher, Rainey-Smith Stephanie, Salvado Olivier, Martins Ralph N, Rowe Christopher C, Masters Colin L, Maruff Paul

Abstract excerpt

BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer's disease (AD) dementia before the age of 80 has been recognized for over 30 years. However, the timing and mode of action of APOE is not understood, nor has there been a detailed analysis of the effect of APOE genotype on memory, hippocampal volume, and amyloid-β (Aβ) levels in cognitively normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28550258
DOI: 10.3233/JAD-170072

Genes

APOE

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